Iloprost Medication: Uses, Dosage, and Administration Guide

Key Points About Iloprost Medication

Iloprost is a medication used to treat conditions related to poor blood flow, such as pulmonary arterial hypertension (PAH) and Raynaud’s phenomenon. It works by widening blood vessels, improving circulation, and relieving symptoms like shortness of breath and pain. Iloprost is administered either through inhalation or intravenous infusion. Always consult your healthcare provider before starting or adjusting your dose. Our telemedicine providers are available to assist with any questions you may have.

Iloprost Medication Names

US Brand Name: Ventavis

Generic Name: Iloprost

The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this article, the generic name will be shown in parentheses.

Pharmacologic Category of Iloprost

Prostacyclin Analog

Vasodilator

Iloprost Dosage Guidelines

Iloprost is prescribed for various conditions, with dosing tailored to the specific condition being treated. Always follow your doctor’s instructions and consult a healthcare provider before making any changes to your dose. You can also connect with one of our telemedicine providers for guidance.

Iloprost for Pulmonary Arterial Hypertension (PAH)

Inhalation: 2.5 mcg to 5 mcg inhaled 6 to 9 times daily, spaced at least 2 hours apart. Treatment is ongoing and should be regularly monitored by your healthcare provider.

Iloprost for Raynaud’s Phenomenon

Intravenous (IV) Infusion: 0.5 to 2 ng/kg/min over 6 hours, typically administered over several days. Treatment duration may vary based on symptom severity and response.

Iloprost for Digital Ulcers

Intravenous (IV) Infusion: 0.5 to 2 ng/kg/min over 6 hours, repeated for 3 to 5 days. Treatment may be repeated as needed based on ulcer healing and symptom improvement.

Iloprost for Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Inhalation: 2.5 mcg to 5 mcg inhaled 6 to 9 times daily. Treatment is long-term and should be adjusted based on symptom control and tolerance.

Iloprost for Scleroderma

Intravenous (IV) Infusion: 0.5 to 2 ng/kg/min over 6 hours, typically administered over several days. Treatment may be repeated periodically depending on symptom severity.

Iloprost for Eisenmenger Syndrome

Inhalation: 2.5 mcg to 5 mcg inhaled 6 to 9 times daily. Long-term treatment is often necessary, and regular follow-ups with your healthcare provider are important.

Iloprost for Peripheral Vascular Disease

Intravenous (IV) Infusion: 0.5 to 2 ng/kg/min over 6 hours, typically administered for several days. Treatment may be repeated based on symptom improvement.

Iloprost for Ischemic Heart Disease

Intravenous (IV) Infusion: 0.5 to 2 ng/kg/min over 6 hours. Treatment duration depends on the severity of the condition and response to therapy.

Iloprost for Acute Respiratory Distress Syndrome (ARDS)

Inhalation: 2.5 mcg to 5 mcg inhaled 6 to 9 times daily. Treatment is typically short-term and should be closely monitored by your healthcare provider.

Iloprost for Heart Failure

Intravenous (IV) Infusion: 0.5 to 2 ng/kg/min over 6 hours. Treatment may be repeated based on symptom control and patient response.

Iloprost Dosage Forms and Strengths

Inhalation Solution: 10 mcg/mL (as Ventavis)

Intravenous Solution: 50 mcg/0.5 mL

Iloprost Administration Guidelines

Iloprost is administered either through inhalation or intravenous infusion. For inhalation, a nebulizer device delivers the medication directly to your lungs. Be sure to follow the instructions provided by your healthcare provider or pharmacist carefully. For intravenous administration, the medication is given through a vein by a healthcare professional. It is important to attend all scheduled appointments and follow-up visits to monitor your response to treatment.

Iloprost Contraindications

A contraindication is a condition where a medication should not be used because it may be harmful. It’s essential to know if you have any of these conditions before starting Iloprost, as it could lead to serious side effects or complications.

Allergy to Iloprost: If you are allergic to Iloprost or any of its ingredients, you should not take this medication. An allergic reaction could cause symptoms like rash, swelling, or difficulty breathing.

Severe Liver Disease: Iloprost is processed by the liver, and if your liver is not functioning properly, the medication may build up in your system, leading to toxicity or worsening of your condition.

Severe Low Blood Pressure (Hypotension): Iloprost can lower blood pressure, so if you already have very low blood pressure, taking this medication could cause dizziness, fainting, or even shock.

Active Bleeding Disorders: Iloprost can increase the risk of bleeding. If you have a condition affecting your ability to clot blood, such as hemophilia, or if you are taking blood thinners, it may not be safe to use.

Iloprost Drug Interactions

Iloprost can interact with other medications, increasing the risk of side effects or reducing the effectiveness of either drug. Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements.

Blood Thinners (Anticoagulants): Medications like warfarin (Coumadin) or heparin can increase the risk of bleeding when taken with Iloprost.

Antihypertensives: Drugs used to lower blood pressure, such as lisinopril (Zestril) or amlodipine (Norvasc), may cause your blood pressure to drop too low when combined with Iloprost.

Vasodilators: Medications like nitroglycerin (Nitrostat) or sildenafil (Viagra) that widen blood vessels can amplify the blood pressure-lowering effects of Iloprost, leading to dizziness or fainting.

NSAIDs: Nonsteroidal anti-inflammatory drugs like ibuprofen (Advil, Motrin) or aspirin may increase the risk of bleeding when taken with Iloprost.

Iloprost in Pregnancy

Is it safe to take Iloprost during pregnancy?

There is limited information on the use of Iloprost in pregnant women. Animal studies suggest potential risks to the developing fetus, but there are no well-controlled studies in humans. If you are pregnant or planning to become pregnant, it is essential to discuss the potential risks and benefits of Iloprost with your healthcare provider. They may recommend alternative treatments or closely monitor your condition if Iloprost is deemed necessary.

Iloprost while Breastfeeding

Is it safe to take Iloprost while breastfeeding?

It is not clear whether Iloprost passes into breast milk. Due to the possibility of serious side effects in a nursing infant, it is important to consult your healthcare provider before using Iloprost while breastfeeding. Your provider may suggest alternative treatments or advise you to discontinue breastfeeding while taking the medication.

Estimated Cost of Iloprost Medication

The cost of Iloprost can vary depending on your location and pharmacy. Without insurance, a 30-day supply using a GoodRx coupon is estimated to range between $2,000 and $3,000. For the most accurate pricing, check with your pharmacy, and consider using a coupon or discount program to help reduce the cost.

Possible Alternatives to Iloprost

For conditions treated with Iloprost, there may be alternative treatments or lifestyle changes that can help manage symptoms. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers for personalized advice.

Pulmonary Arterial Hypertension (PAH)

Alternative treatments include medications such as sildenafil (Revatio) or bosentan (Tracleer). Lifestyle modifications, including regular exercise, a low-sodium diet, and avoiding high altitudes, may also help manage PAH symptoms.

Raynaud’s Phenomenon

Calcium channel blockers like nifedipine (Procardia) or lifestyle adjustments, such as avoiding cold temperatures and managing stress, can help reduce symptoms.

Digital Ulcers

In addition to Iloprost, treatment options may include wound care, antibiotics for infections, and other vasodilators like sildenafil (Viagra).

Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Surgical options, such as pulmonary endarterectomy, or medications like riociguat (Adempas) may be considered for treating CTEPH.

Scleroderma

Treatment options for scleroderma include immunosuppressive drugs like methotrexate or mycophenolate mofetil (CellCept), along with physical therapy to help maintain flexibility.

Eisenmenger Syndrome

Treatment may involve oxygen therapy, medications like bosentan (Tracleer), or, in severe cases, heart-lung transplantation.

Peripheral Vascular Disease

Lifestyle changes, such as quitting smoking and engaging in regular exercise, along with medications like cilostazol (Pletal), can help improve blood flow.

Ischemic Heart Disease

Alternatives include medications like beta-blockers (e.g., metoprolol) or statins (e.g., atorvastatin), along with lifestyle changes such as following a heart-healthy diet and maintaining regular physical activity.

Acute Respiratory Distress Syndrome (ARDS)

Treatment for ARDS typically involves mechanical ventilation and supportive care in a hospital setting. While there are no direct medication alternatives to Iloprost for ARDS, your healthcare provider may recommend other supportive therapies.

Heart Failure

Alternative treatments for heart failure include medications like ACE inhibitors (e.g., lisinopril), beta-blockers (e.g., carvedilol), and lifestyle changes such as reducing salt intake and maintaining a healthy weight.

Recent Updates on Iloprost Research

Recent studies have explored the potential benefits of Iloprost in treating conditions beyond its current approved uses. For instance, ongoing research is investigating its role in improving outcomes for patients with severe COVID-19-related lung damage, including acute respiratory distress syndrome (ARDS). Additionally, studies are examining the use of Iloprost in combination with other therapies to enhance its effectiveness in treating pulmonary arterial hypertension (PAH).

While these studies are promising, further research is needed to confirm the safety and efficacy of Iloprost in these new areas. Always consult your healthcare provider before making any changes to your treatment plan. If you have questions about Iloprost or its potential benefits for your condition, consider scheduling a telemedicine appointment with one of our providers for personalized advice.

James Kingsley

Learn More