Estradiol Valerate: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Estradiol Valerate is a form of estrogen used to treat conditions related to hormone imbalances, such as menopause symptoms, hormone replacement therapy (HRT), and certain cancers. It helps alleviate hot flashes, vaginal dryness, and bone loss. Estradiol Valerate is also commonly used in gender-affirming hormone therapy. Always consult a healthcare provider before starting or adjusting your dose. Our telemedicine providers are available to assist with any questions you may have.

Names of Medication

US Brand Name: Delestrogen

Generic Name: Estradiol Valerate

The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this article, the generic name will be listed in parentheses.

Pharmacologic Category

Category: Estrogens

Therapy Type: Hormone Replacement Therapy (HRT)

Estradiol Valerate Dosage

Estradiol Valerate is prescribed for various conditions, with dosage and frequency tailored to the specific condition being treated. Always consult your doctor before making any changes to your medication. You can also schedule a telemedicine appointment with one of our providers for personalized advice.

Menopause

Dosage: 10 to 20 mg every 4 weeks

Duration: The length of treatment varies based on individual needs and response to therapy. Your doctor will determine the appropriate duration.

Hormone Replacement Therapy (HRT)

Dosage: 10 to 20 mg every 4 weeks

Duration: Long-term treatment may be necessary, depending on the severity of symptoms and overall health.

Osteoporosis Prevention

Dosage: 10 to 20 mg every 4 weeks

Duration: Typically long-term to maintain bone density and reduce the risk of fractures.

Hypogonadism

Dosage: 10 to 20 mg every 4 weeks

Duration: Treatment duration depends on the underlying cause and response to therapy.

Primary Ovarian Insufficiency

Dosage: 10 to 20 mg every 4 weeks

Duration: Long-term treatment may be required to manage symptoms effectively.

Endometriosis

Dosage: 10 to 20 mg every 4 weeks

Duration: Treatment duration varies based on symptom severity and response to therapy.

Uterine Bleeding

Dosage: 10 to 20 mg every 4 weeks

Duration: Typically short-term to manage acute symptoms.

Breast Cancer (Palliative Treatment)

Dosage: 30 mg every 1 to 2 weeks

Duration: Treatment duration depends on individual response and overall health.

Prostate Cancer (Palliative Treatment)

Dosage: 30 mg every 1 to 2 weeks

Duration: Long-term treatment may be necessary depending on disease progression.

Gender Dysphoria (Gender-Affirming Hormone Therapy)

Dosage: 10 to 20 mg every 2 to 4 weeks

Duration: Long-term treatment is often required for gender-affirming hormone therapy.

Dosage Forms and Strengths

Injection, intramuscular: 10 mg/mL, 20 mg/mL, 40 mg/mL

How to Administer Estradiol Valerate Injections

Estradiol Valerate is administered via intramuscular injection, typically by a healthcare provider. If you are self-administering at home, ensure you are properly trained in injection techniques. Rotate injection sites to minimize irritation. Always follow your doctor’s instructions and never adjust your dose without consulting them first. If you have any questions, our telemedicine providers are available to guide you through the process.

Estradiol Valerate Side Effects and Adverse Reactions

Like all medications, Estradiol Valerate can cause side effects. While not everyone experiences them, it’s important to be aware of potential reactions. Contact your healthcare provider immediately if you experience any severe side effects.

Common Side Effects (1% to 10%): Headache, nausea, breast tenderness, bloating, and mood changes.

Less Common Side Effects (0.1% to 1%): Weight changes, changes in libido, and skin discoloration.

Rare Side Effects (<0.1%): Blood clots, stroke, heart attack, and liver problems.

Contraindications for Estradiol Valerate

A contraindication is a specific situation or condition where a medication should not be used because it may cause harm. For Estradiol Valerate, several conditions make its use dangerous or harmful. Below is a list of contraindications and explanations for why Estradiol Valerate should be avoided in these situations:

1. History of blood clots (deep vein thrombosis, pulmonary embolism): Estradiol Valerate can increase the risk of blood clots, leading to serious complications like stroke or heart attack.
2. Known or suspected breast cancer: Estradiol Valerate, as a form of estrogen, can promote the growth of certain breast cancer cells.
3. Undiagnosed abnormal vaginal bleeding: This could indicate a more serious condition, such as endometrial cancer, and should be evaluated before starting estrogen therapy.
4. Liver disease: Estradiol Valerate is metabolized by the liver, and impaired liver function can lead to drug accumulation, increasing the risk of side effects.
5. Pregnancy: Estrogens like Estradiol Valerate should not be used during pregnancy as they can harm the developing fetus.
6. Allergy to estradiol or any component of the medication: If you have a known allergy to estradiol or any inactive ingredients in Estradiol Valerate, you should not take this medication.

If you have any of these conditions, discuss them with your healthcare provider before starting Estradiol Valerate. If you’re unsure, our telemedicine providers are available to help review your medical history and determine if this medication is right for you.

Drug to Drug Interactions

Estradiol Valerate can interact with other medications, potentially reducing its effectiveness or increasing the risk of side effects. Below are some common medications that may interact with Estradiol Valerate:

1. Rifampin (Rifadin): This antibiotic can decrease the effectiveness of Estradiol Valerate by accelerating its metabolism in the liver.
2. Phenytoin (Dilantin): This anti-seizure medication can also reduce the effectiveness of Estradiol Valerate by increasing its breakdown in the liver.
3. Carbamazepine (Tegretol): Another anti-seizure medication that can lower Estradiol Valerate levels in the body, making it less effective.
4. St. John’s Wort: This herbal supplement can reduce the effectiveness of Estradiol Valerate by speeding up its metabolism.
5. Warfarin (Coumadin): Estradiol Valerate may interfere with blood-thinning medications, increasing the risk of bleeding or clotting complications.

Always inform your healthcare provider about all medications and supplements you are taking before starting Estradiol Valerate. If you are concerned about potential interactions, one of our telemedicine providers can review your current medications and offer personalized guidance.

Estradiol Valerate in Pregnancy

Is it Safe to Take Estradiol Valerate During Pregnancy?

No, Estradiol Valerate is not safe during pregnancy. Estrogens, including Estradiol Valerate, can harm the developing fetus and may increase the risk of birth defects. If you become pregnant while taking this medication, stop immediately and contact your healthcare provider. If you are planning to become pregnant, discuss alternative treatments with your provider beforehand.

Estradiol Valerate While Breastfeeding

Is it Safe to Take Estradiol Valerate While Breastfeeding?

Estradiol Valerate is generally not recommended while breastfeeding. Estrogen can pass into breast milk and may affect milk production or have undesirable effects on the nursing infant. If you are breastfeeding or planning to breastfeed, talk to your healthcare provider about safer alternatives. Our telemedicine providers are available to discuss your options and help you make an informed decision.

Estimated Cost of Estradiol Valerate

The cost of a 30-day supply of Estradiol Valerate without insurance can vary depending on the pharmacy and location. However, using a GoodRx coupon, the estimated cost is around $30 to $50. Prices may fluctuate, so it’s always a good idea to check for the latest discounts and offers.

Possible Alternatives to Estradiol Valerate

If Estradiol Valerate is not suitable for you, there are alternative treatments and lifestyle changes that may help manage your condition. Always discuss any changes with your healthcare provider before adjusting your treatment plan. Here are some alternatives for specific conditions:

1. Menopause: Alternatives include non-hormonal medications like SSRIs (e.g., paroxetine) or lifestyle changes such as regular exercise, a balanced diet, and stress management techniques.
2. Hormone Replacement Therapy (HRT): Other forms of HRT include transdermal patches, gels, or bioidentical hormone therapy. Non-hormonal options like gabapentin may also help alleviate symptoms.
3. Osteoporosis: Bisphosphonates (e.g., alendronate), calcium and vitamin D supplements, and weight-bearing exercises can help maintain bone health.
4. Hypogonadism: Testosterone replacement therapy may be considered for men, while lifestyle changes like weight loss and regular physical activity can also improve symptoms.
5. Primary Ovarian Insufficiency: Hormone therapy with estrogen and progesterone is commonly used, but non-hormonal options like calcium and vitamin D supplements may also be beneficial.
6. Endometriosis: Non-hormonal treatments include NSAIDs (e.g., ibuprofen) for pain relief or surgical options to remove endometrial tissue.
7. Uterine Bleeding: Non-hormonal treatments include NSAIDs or tranexamic acid to reduce bleeding. Surgical options like endometrial ablation may also be considered.
8. Breast Cancer: Hormonal therapies like tamoxifen or aromatase inhibitors are commonly used. Discuss with your oncologist for the best treatment plan.
9. Prostate Cancer: Androgen deprivation therapy (ADT) or medications like leuprolide (Lupron) may be used to manage prostate cancer.
10. Gender Dysphoria: Alternatives include other forms of estrogen therapy, such as estradiol patches or gels, or non-hormonal approaches like counseling and social support.

If you are considering any of these alternatives, our telemedicine providers can help guide you through your options and develop a treatment plan tailored to your needs.

Recent Updates on Estradiol Valerate Research

Recent studies have focused on the long-term safety of Estradiol Valerate, particularly its effects on cardiovascular health and cancer risk. Some research suggests that when used in appropriate doses and for limited durations, the risks may be lower than previously thought, especially in younger women or those who start hormone therapy soon after menopause. However, more research is needed to fully understand the long-term effects. Ongoing studies are also exploring the use of Estradiol Valerate in gender-affirming hormone therapy, with promising results in terms of safety and efficacy.

It’s important to stay informed about the latest research, and our providers are available to discuss how new findings may impact your treatment plan. If you have any concerns or questions, don’t hesitate to schedule a telemedicine consultation with one of our healthcare professionals.

James Kingsley

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