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Edoxaban Medication: Uses, Dosage, Side Effects & Interactions
Summary of Key Points
Edoxaban is a prescription medication used to prevent and treat blood clots, including conditions such as atrial fibrillation, deep vein thrombosis (DVT), and pulmonary embolism (PE). It works by inhibiting specific proteins in the blood that contribute to clot formation. By doing so, Edoxaban helps lower the risk of stroke and other serious complications. Always consult your healthcare provider before starting or adjusting your medication. If you need personalized care, consider scheduling a telemedicine visit with one of our providers.
Names of Medication
US Brand Name: Savaysa
Generic Name: Edoxaban
The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this article, the generic name will be listed in parentheses.
Pharmacologic Category
Factor Xa Inhibitors
Anticoagulants
Edoxaban Dosage
Edoxaban is prescribed for various conditions related to blood clots. The dosage and frequency depend on the specific condition being treated. Always follow your healthcare provider’s instructions and never adjust your dose without consulting them. If you have any concerns, our telemedicine providers are available to assist you.
Edoxaban for Atrial Fibrillation (AFib)
Dosage: 60 mg once daily
Duration: Long-term treatment to reduce the risk of stroke and systemic embolism.
Edoxaban for Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE)
Dosage: 60 mg once daily after 5 to 10 days of initial treatment with a parenteral anticoagulant.
Duration: Typically 3 to 6 months, but may be extended based on your doctor’s recommendations.
Edoxaban for Thromboembolic Stroke
Dosage: 60 mg once daily
Duration: Long-term treatment to prevent stroke in patients with atrial fibrillation.
Edoxaban for Venous Thromboembolism (VTE)
Dosage: 60 mg once daily
Duration: Typically 3 to 6 months, though your doctor may recommend longer treatment depending on your condition.
Edoxaban for Myocardial Infarction (Heart Attack)
Dosage: 60 mg once daily
Duration: As directed by your healthcare provider, based on your risk factors and recovery progress.
Edoxaban for Peripheral Artery Disease (PAD) and Coronary Artery Disease (CAD)
Dosage: 60 mg once daily
Duration: Long-term treatment to reduce the risk of cardiovascular events.
Edoxaban and Heart Valve Replacement
Dosage: Not typically recommended for patients with mechanical heart valves. Consult your doctor for alternative treatments.
Edoxaban for Aortic Aneurysm
Dosage: 60 mg once daily
Duration: As directed by your healthcare provider, depending on your specific condition and risk factors.
Dosage Forms and Strengths of Edoxaban
Tablet: 15 mg
Tablet: 30 mg
Tablet: 60 mg
Administration Instructions for Edoxaban
Edoxaban should be taken once daily, with or without food. Swallow the tablet whole with a glass of water. It’s important to take it at the same time each day to maintain consistent levels in your bloodstream. If you miss a dose, take it as soon as you remember, unless it’s almost time for your next dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor’s instructions carefully, and reach out to our telemedicine team if you have any questions or concerns about how to take your medication.
Contraindications for Edoxaban
A contraindication is a specific situation or condition where a particular treatment or medication should not be used because it may be harmful. If you have any of the following conditions, you should not take Edoxaban. Always consult with your healthcare provider, and if you’re unsure, you can schedule a telemedicine appointment with one of our providers.
- Active bleeding: Edoxaban is a blood thinner, and taking it while you have active bleeding (such as gastrointestinal bleeding) can worsen the bleeding.
- Severe kidney disease: Edoxaban is processed by the kidneys. If your kidneys are not functioning properly, the medication may accumulate in your body, increasing the risk of bleeding.
- Prosthetic heart valves: Edoxaban is not recommended for patients with mechanical heart valves, as it has not been shown to be effective in preventing blood clots in these patients.
- Allergy to Edoxaban: If you have had an allergic reaction to Edoxaban or any of its ingredients, you should not take it.
- Pregnancy: Edoxaban is not recommended during pregnancy due to potential risks to the fetus (see more details below).
Edoxaban Drug Interactions
Edoxaban can interact with other medications, which may increase the risk of bleeding or reduce the effectiveness of the drug. Be sure to inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. Below are some common medications that interact with Edoxaban:
- Rifampin (Rifadin): This antibiotic can reduce the effectiveness of Edoxaban by increasing its breakdown in the body.
- Ketoconazole (Nizoral): This antifungal medication can increase the levels of Edoxaban in your blood, raising the risk of bleeding.
- Clopidogrel (Plavix): This antiplatelet drug can increase the risk of bleeding when taken with Edoxaban.
- Warfarin (Coumadin): Taking both Warfarin and Edoxaban can significantly increase the risk of bleeding, as both are blood thinners.
- Nonsteroidal anti-inflammatory drugs (NSAIDs): Medications like ibuprofen (Advil, Motrin) and naproxen (Aleve) can increase the risk of bleeding when taken with Edoxaban.
Edoxaban in Pregnancy
Is it safe to take Edoxaban when pregnant?
Edoxaban is generally not recommended during pregnancy. Blood thinners like Edoxaban can cross the placenta, potentially posing risks to the developing fetus, including bleeding complications. If you are pregnant or planning to become pregnant, it is essential to consult your healthcare provider about safer alternatives. You can also schedule a telemedicine appointment with one of our providers to explore other treatment options that may be more appropriate during pregnancy.
Edoxaban while Breastfeeding
Is it safe to take Edoxaban while breastfeeding?
There is limited information on whether Edoxaban passes into breast milk. Due to the potential risk of bleeding in a nursing infant, it is generally advised to avoid Edoxaban while breastfeeding. If you require anticoagulation therapy, speak with your healthcare provider to discuss safer alternatives that can be used during this time.
Estimated Cost of Edoxaban Medication
The cost of a 30-day supply of Edoxaban (60 mg) without insurance can vary depending on the pharmacy and location. With a GoodRx coupon, the price typically ranges from $400 to $500 for a 30-day supply. For the most accurate pricing, check with your local pharmacy, and consider using a coupon to help reduce the cost.
Possible Alternatives to Edoxaban
If Edoxaban is not suitable for you, or if you’re exploring other treatment options, several alternatives are available. Always discuss any changes to your treatment plan with your healthcare provider, and consider scheduling a telemedicine appointment for personalized advice.
Atrial Fibrillation
Alternatives to Edoxaban include anticoagulants such as Warfarin (Coumadin) or Apixaban (Eliquis). In addition to medication, lifestyle changes like maintaining a healthy weight, reducing alcohol consumption, and managing high blood pressure can help lower the risk of complications.
Deep Vein Thrombosis (DVT)
Other blood thinners, such as Rivaroxaban (Xarelto) or Dabigatran (Pradaxa), may be considered. Additionally, wearing compression stockings and engaging in regular physical activity can help prevent DVT.
Pulmonary Embolism (PE)
In cases of pulmonary embolism, alternatives to Edoxaban include Warfarin or Apixaban. Staying active and avoiding prolonged periods of immobility can also help reduce the risk of PE.
Thromboembolic Stroke
For the prevention of thromboembolic stroke, alternatives include Apixaban or Warfarin. Managing underlying conditions such as high blood pressure, cholesterol, and diabetes is also crucial in reducing stroke risk.
Venous Thromboembolism (VTE)
Other anticoagulants, such as Rivaroxaban or Warfarin, may be used to treat venous thromboembolism. Regular exercise and maintaining a healthy weight are important lifestyle measures to help prevent VTE.
Myocardial Infarction (Heart Attack)
In addition to blood thinners, medications like aspirin or beta-blockers may be prescribed following a heart attack. Lifestyle changes, including quitting smoking, adopting a heart-healthy diet, and exercising regularly, are essential for long-term heart health.
Peripheral Artery Disease (PAD)
Treatment options for peripheral artery disease include antiplatelet medications such as Clopidogrel (Plavix) or aspirin. Regular physical activity, smoking cessation, and managing cholesterol levels are key lifestyle changes that can improve outcomes.
Coronary Artery Disease (CAD)
For coronary artery disease, medications like aspirin or statins may be recommended. Lifestyle modifications, including a heart-healthy diet, regular exercise, and quitting smoking, are critical for managing CAD effectively.
Heart Valve Replacement
For patients with mechanical heart valves, Warfarin is often preferred over Edoxaban. It is important to discuss with your healthcare provider the best anticoagulation strategy for your specific condition.
Aortic Aneurysm
While Edoxaban is not typically used to treat aortic aneurysms, managing blood pressure with medications like beta-blockers and making lifestyle changes, such as quitting smoking, can help reduce the risk of complications.
Recent Updates on Edoxaban Research
Recent studies have explored Edoxaban’s effectiveness in various patient populations. A 2022 study examined its use in patients with cancer-associated venous thromboembolism (VTE) and found it to be as effective as low-molecular-weight heparin in preventing recurrent VTE, with a similar safety profile. Another ongoing study is investigating Edoxaban in patients with atrial fibrillation and chronic kidney disease, aiming to determine whether it is a safer alternative to Warfarin for this population.
As research continues, staying informed about new findings is important. If you have any questions or concerns about your treatment, consider scheduling a telemedicine appointment with one of our providers to discuss the latest research and how it may impact your care.
