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Chorionic Gonadotropin: Uses, Benefits, and Dosage Guidelines
Summary of Key Points
Chorionic Gonadotropin, commonly referred to as Human Chorionic Gonadotropin (hCG), is a hormone used to treat conditions such as infertility, hypogonadism, and certain testicular disorders. It works by stimulating the production of sex hormones in both men and women, making it a key component in fertility treatments and hormone therapies. Always consult your healthcare provider before starting or adjusting your dosage. You can also schedule a telemedicine appointment with one of our providers for personalized advice.
Names of Medication
US Brand Names: Pregnyl, Novarel, Ovidrel
Generic Name: Chorionic Gonadotropin (hCG)
The generic name refers to the drug’s chemical composition, while the brand name is assigned by the manufacturer. In this article, the generic name is listed in parentheses.
Pharmacologic Category
Categories:
- Gonadotropin
- Hormone Therapy
Dosing Guidelines for Chorionic Gonadotropin
Chorionic Gonadotropin is prescribed for a variety of conditions, and the dosage will vary depending on the specific condition being treated. It is essential to follow your doctor’s instructions carefully and consult your healthcare provider before making any changes to your dose. You can schedule a telemedicine visit with one of our providers for personalized guidance.
Infertility in Women
Dosage: 5,000 to 10,000 units injected once after the last dose of menotropins or clomiphene.
Frequency: Single dose.
Hypogonadism in Men
Dosage: 500 to 1,000 units injected three times a week for three weeks, followed by the same dose twice a week for three weeks.
Frequency: Initially three times a week, then twice a week.
Cryptorchidism (Undescended Testicles in Boys)
Dosage: 4,000 units injected three times a week for three weeks, or 1,000 units three times a week for six weeks.
Frequency: Three times a week.
Oligospermia (Low Sperm Count)
Dosage: 1,000 to 2,000 units injected two to three times a week for several months.
Frequency: Two to three times a week.
Anovulation (Absence of Ovulation)
Dosage: 5,000 to 10,000 units injected once after the last dose of menotropins or clomiphene.
Frequency: Single dose.
Testicular Atrophy (Shrinking of Testicles)
Dosage: 500 to 1,000 units injected three times a week for three weeks, followed by the same dose twice a week for three weeks.
Frequency: Initially three times a week, then twice a week.
Luteal Phase Defect
Dosage: 5,000 to 10,000 units injected once after the last dose of menotropins or clomiphene.
Frequency: Single dose.
Polycystic Ovary Syndrome (PCOS)
Dosage: 5,000 to 10,000 units injected once after the last dose of menotropins or clomiphene.
Frequency: Single dose.
Male Hypogonadism
Dosage: 500 to 1,000 units injected three times a week for three weeks, followed by the same dose twice a week for three weeks.
Frequency: Initially three times a week, then twice a week.
Amenorrhea (Absence of Menstrual Periods)
Dosage: 5,000 to 10,000 units injected once after the last dose of menotropins or clomiphene.
Frequency: Single dose.
Dosage Forms and Strengths of Chorionic Gonadotropin
Injection: Available in 5,000 units/mL and 10,000 units/mL strengths.
Contraindications for Chorionic Gonadotropin
A contraindication is a specific condition where a medication should not be used due to the risk of harm. It is important to be aware of any contraindications before starting Chorionic Gonadotropin, as using it in these cases could lead to serious health complications.
Allergy to Chorionic Gonadotropin: If you are allergic to Chorionic Gonadotropin or any of its components, taking this medication could trigger a severe allergic reaction, which may include symptoms such as rash, swelling, or difficulty breathing.
Precocious Puberty: Chorionic Gonadotropin can exacerbate this condition by stimulating early sexual development in children, potentially leading to growth and developmental issues.
Prostate Cancer: Since Chorionic Gonadotropin can increase testosterone levels, it may worsen prostate cancer or promote the growth of cancer cells.
Uncontrolled Thyroid or Adrenal Disorders: These conditions can interfere with how Chorionic Gonadotropin functions, leading to unpredictable or harmful effects.
Ovarian Cysts: In women, Chorionic Gonadotropin can cause ovarian enlargement. If you already have ovarian cysts, this could lead to complications such as rupture.
Drug-to-Drug Interactions
Chorionic Gonadotropin may interact with other medications, potentially affecting its effectiveness or increasing the risk of side effects. Always inform your healthcare provider about any medications you are taking, including over-the-counter drugs and supplements.
Clomiphene (Clomid): Commonly used in fertility treatments, combining Clomiphene with Chorionic Gonadotropin can increase the risk of ovarian hyperstimulation syndrome (OHSS), a condition that can lead to serious complications.
Gonadotropin-Releasing Hormone Agonists (Lupron, Leuprolide): These medications, also used in fertility treatments, can interact with Chorionic Gonadotropin, potentially leading to overstimulation of the ovaries.
Androgens (Testosterone, AndroGel): Since Chorionic Gonadotropin increases testosterone levels, combining it with additional testosterone can result in excessive hormone levels, which may cause side effects such as mood swings, acne, or even cardiovascular issues.
Anticoagulants (Warfarin, Coumadin): Chorionic Gonadotropin may increase the risk of bleeding when taken with blood thinners, so careful monitoring is necessary.
Chorionic Gonadotropin in Pregnancy
Chorionic Gonadotropin is generally not recommended during pregnancy. While it can assist in achieving conception, the medication is typically discontinued once pregnancy is confirmed. Continuing Chorionic Gonadotropin during pregnancy may increase the risk of complications. If you become pregnant while using this medication, it is important to consult your healthcare provider right away.
Chorionic Gonadotropin While Breastfeeding
There is limited information on whether Chorionic Gonadotropin passes into breast milk or affects a nursing infant. Due to the lack of comprehensive data, it is usually advised to avoid using this medication while breastfeeding unless specifically recommended by your healthcare provider. If you require fertility treatment or hormone therapy while breastfeeding, discuss safer alternatives with your provider to ensure the best outcome for both you and your baby.
Estimated Cost of Chorionic Gonadotropin
The cost of Chorionic Gonadotropin can vary depending on the dosage and the pharmacy. Without insurance, a 30-day supply using a GoodRX coupon is estimated to range between $150 and $250. Prices may fluctuate, so it’s a good idea to check with your local pharmacy or use a prescription discount service like GoodRX for the most up-to-date pricing information.
Possible Alternatives to Chorionic Gonadotropin
If Chorionic Gonadotropin is not the right option for you, there are other treatments available depending on your specific condition. Always consult your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to help you explore these alternatives.
Infertility
Alternative treatments include fertility medications such as Clomiphene (Clomid) or Letrozole (Femara). Assisted reproductive technologies, like in vitro fertilization (IVF), may also be considered based on individual circumstances.
Hypogonadism
Testosterone replacement therapy (TRT) is a common alternative for treating hypogonadism. Additionally, lifestyle changes, such as weight loss and regular exercise, may help alleviate symptoms.
Cryptorchidism
Surgery (orchiopexy) is the standard treatment for undescended testicles. Hormonal treatments, such as Gonadotropin-Releasing Hormone (GnRH), may also be an option in certain cases.
Oligospermia
Lifestyle modifications, such as reducing alcohol consumption, quitting smoking, and improving diet, can positively impact sperm count. Medications like Clomiphene or antioxidants may also be prescribed to enhance sperm production.
Anovulation
Medications like Clomiphene or Letrozole are commonly used to stimulate ovulation. In addition, lifestyle changes, such as weight management and stress reduction, can support ovulatory function.
Testicular Atrophy
Testosterone replacement therapy or lifestyle adjustments, including a balanced diet and regular exercise, may help address testicular atrophy. It is also important to treat any underlying conditions, such as hypogonadism, that may be contributing to the issue.
Luteal Phase Defect
Progesterone supplementation is often used to improve luteal phase function. Additionally, lifestyle changes, such as managing stress and maintaining a healthy weight, can be beneficial in addressing this condition.
Polycystic Ovary Syndrome (PCOS)
Lifestyle changes, including weight loss, regular exercise, and a healthy diet, are often the first-line treatments for PCOS. Medications like Metformin or Clomiphene may also be prescribed to help regulate ovulation.
Male Hypogonadism
Testosterone replacement therapy is a widely used treatment for male hypogonadism. Lifestyle improvements, such as adopting a healthier diet and increasing physical activity, may also help manage symptoms.
Amenorrhea
Hormonal treatments, such as birth control pills or progesterone therapy, are often prescribed to regulate menstrual cycles. Lifestyle changes, including stress management and maintaining a healthy weight, can also play a significant role in treatment.
Recent Updates on Chorionic Gonadotropin Research
Recent studies have investigated the use of Chorionic Gonadotropin in combination with other fertility treatments to enhance success rates in assisted reproductive technologies like IVF. Ongoing research is also exploring its role in treating male hypogonadism and its long-term effects on testosterone levels. Additionally, there is growing interest in the potential use of Chorionic Gonadotropin for weight loss, although more research is needed to confirm its safety and effectiveness in this area.
As new studies continue to emerge, staying informed is essential. If you have any questions about how recent research might affect your treatment plan, feel free to reach out to one of our telemedicine providers for personalized guidance.
