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Cholecalciferol: Vitamin D3 Benefits, Dosage, and Side Effects Explained
Summary or Key Points
Cholecalciferol, commonly known as Vitamin D3, is a medication used to treat and prevent conditions related to Vitamin D deficiency, such as osteoporosis, rickets, and osteomalacia. It plays a crucial role in calcium absorption, promoting healthy bones. Available in various forms and strengths, the appropriate dosage depends on the specific condition being treated. Always consult your healthcare provider before starting or adjusting your Cholecalciferol dose.
Names of Medication
US Brand Names: D-Vi-Sol, Decara, Delta D3, Vitamin D3
Cholecalciferol is the generic name for this medication. A generic name refers to the official medical name of the active ingredient in the drug. The generic name is typically listed in parentheses after the brand name.
Pharmacologic Category
Vitamin D Analog
Fat-Soluble Vitamin
Cholecalciferol Dosage
Cholecalciferol is used to treat a variety of conditions, with the dosage varying based on the specific condition. Always consult your healthcare provider before adjusting your dose. You can also schedule a telemedicine appointment with one of our providers for personalized guidance.
Osteoporosis
Dosage: 800-1000 IU (International Units) daily, typically combined with calcium supplements.
Length of Treatment: Long-term, as directed by your healthcare provider.
Rickets
Dosage: 12,000 to 500,000 IU daily or weekly, depending on the severity of the condition.
Length of Treatment: Typically 6-12 weeks or as directed by your healthcare provider.
Osteomalacia
Dosage: 10,000 to 50,000 IU weekly or daily, depending on the severity of the condition.
Length of Treatment: Typically 6-12 weeks or as directed by your healthcare provider.
Hypoparathyroidism
Dosage: 50,000 to 200,000 IU daily, often combined with calcium supplements.
Length of Treatment: Long-term, as directed by your healthcare provider.
Vitamin D Deficiency
Dosage: 1,000 to 2,000 IU daily, or 50,000 IU weekly for 6-8 weeks.
Length of Treatment: Typically 6-8 weeks, followed by maintenance therapy as directed by your healthcare provider.
Chronic Kidney Disease
Dosage: 800 to 1,000 IU daily or as directed by your healthcare provider.
Length of Treatment: Long-term, depending on kidney function and calcium levels.
Malabsorption Syndromes
Dosage: 10,000 to 50,000 IU daily, depending on the severity of the condition.
Length of Treatment: Long-term, as directed by your healthcare provider.
Hyperparathyroidism
Dosage: 800 to 1,000 IU daily or as directed by your healthcare provider.
Length of Treatment: Long-term, depending on calcium and parathyroid hormone levels.
Psoriasis
Dosage: Topical application of Vitamin D analogs, as directed by your healthcare provider.
Length of Treatment: As directed by your healthcare provider.
Osteitis Deformans (Paget’s Disease)
Dosage: 800 to 1,000 IU daily or as directed by your healthcare provider.
Length of Treatment: Long-term, depending on calcium levels and bone health.
Dosage Forms and Strengths
Cholecalciferol is available in various forms and strengths, allowing for flexibility in finding the most suitable Vitamin D3 supplement for your needs. The available forms include:
- Capsules: 400 IU, 1,000 IU, 2,000 IU, 5,000 IU, 50,000 IU
- Tablets: 400 IU, 1,000 IU, 2,000 IU, 5,000 IU
- Oral Solution: 400 IU/mL, 800 IU/mL
- Chewable Tablets: 400 IU, 1,000 IU
- Softgels: 1,000 IU, 2,000 IU, 5,000 IU
Administration Instructions
Cholecalciferol can be taken with or without food. If using the liquid form, measure the dose carefully with a special measuring device or spoon. Avoid using a household spoon, as it may not provide the correct dose. For chewable tablets, chew thoroughly before swallowing. Always follow your healthcare provider’s instructions and do not exceed the recommended dose of Vitamin D3.
Adverse Reactions and Side Effects
Like all medications, Cholecalciferol can cause side effects. While most are mild, some may be more serious. Contact your healthcare provider if you experience any of the following:
Common Side Effects: Nausea, vomiting, constipation, dry mouth, or a metallic taste.
Less Common Side Effects: Headache, fatigue, or muscle pain.
Serious Side Effects: High calcium levels (hypercalcemia), which can lead to confusion, irregular heartbeat, or kidney problems. Seek medical attention if you experience these symptoms.
Contraindications
A contraindication is a specific condition or situation where a medication should not be used because it could be harmful. If you have any of the following conditions, avoid taking Cholecalciferol (Vitamin D3) unless advised by your healthcare provider:
Hypercalcemia (High Calcium Levels): Cholecalciferol increases calcium absorption, so if you already have high calcium levels, it could worsen the condition, potentially leading to complications like kidney stones or heart problems.
Vitamin D Toxicity: If you have a history of vitamin D toxicity, taking Cholecalciferol could cause further buildup of vitamin D, leading to dangerously high calcium levels.
Severe Kidney Disease: In patients with severe kidney disease, the body may not process vitamin D properly, leading to imbalances in calcium and phosphorus levels.
Allergic Reaction to Cholecalciferol: If you have had an allergic reaction to Cholecalciferol or any of its ingredients, you should not take this medication.
Granulomatous Diseases (e.g., Sarcoidosis, Tuberculosis): These conditions can increase sensitivity to vitamin D, leading to elevated calcium levels, which can be harmful.
Drug to Drug Interactions
Cholecalciferol can interact with other medications, potentially affecting its effectiveness or increasing the risk of side effects. Inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements. The following medications may interact with Cholecalciferol:
Orlistat (Alli, Xenical): This weight-loss medication can reduce the absorption of fat-soluble vitamins like vitamin D, making Cholecalciferol less effective.
Cholestyramine (Prevalite, Questran): Used to lower cholesterol, this medication can also reduce vitamin D absorption.
Phenytoin (Dilantin) and Phenobarbital: These anti-seizure medications can increase the breakdown of vitamin D in the liver, reducing its effectiveness.
Thiazide Diuretics (Hydrochlorothiazide): These medications can increase calcium levels when taken with Cholecalciferol, potentially leading to hypercalcemia.
Glucocorticoids (Prednisone): Long-term use of corticosteroids can reduce calcium absorption and increase the risk of bone loss, which may require adjustments in vitamin D dosing.
Cholecalciferol in Pregnancy
Is it safe to take Cholecalciferol when pregnant?
Yes, Cholecalciferol (Vitamin D3) is generally considered safe during pregnancy, as vitamin D plays a crucial role in both maternal health and fetal development. However, it’s essential to take the correct dosage. Excessive vitamin D intake can lead to elevated calcium levels, which may cause complications for both the mother and baby. Always consult your healthcare provider before starting or continuing Cholecalciferol during pregnancy. If you need guidance, our telemedicine providers are available to help you determine the appropriate dosage of Vitamin D3 supplements.
Cholecalciferol while Breastfeeding
Is it safe to take Cholecalciferol while breastfeeding?
Yes, Cholecalciferol is safe to take while breastfeeding. Maintaining adequate vitamin D levels is important for both the mother and the breastfeeding infant. However, the amount of vitamin D passed through breast milk may not be sufficient for the baby, so your healthcare provider might recommend a vitamin D supplement for your infant. As always, consult your provider to ensure you are taking the correct dosage of Cholecalciferol. If you have any questions, our telemedicine providers are available to assist you.
Estimated Cost of Cholecalciferol
The cost of a 30-day supply of Cholecalciferol (Vitamin D3) can vary depending on the dosage and brand. Without insurance, using a GoodRx coupon, the estimated cost for a 30-day supply of over-the-counter Cholecalciferol typically ranges from $5 to $15. Prescription-strength versions may be more expensive, so it’s a good idea to check with your pharmacy or use a discount service like GoodRx to find the best price for Vitamin D3 supplements.
Possible Alternatives to Cholecalciferol
Depending on your condition, alternative treatments or lifestyle changes may help manage your health. Always discuss these options with your healthcare provider before making any changes to your treatment plan. Our telemedicine providers are available to help you explore these alternatives.
Osteoporosis
In addition to Cholecalciferol, treatments may include calcium supplements, bisphosphonates (e.g., Alendronate), and lifestyle changes such as weight-bearing exercises and a diet rich in calcium and vitamin D.
Rickets
Treatment typically involves vitamin D and calcium supplementation. In severe cases, corrective surgery may be necessary. Adequate sunlight exposure can also help improve vitamin D levels.
Osteomalacia
Besides Cholecalciferol, calcium and phosphate supplements may be recommended, depending on the underlying cause. Sunlight exposure and dietary changes can also be beneficial.
Hypoparathyroidism
Treatment may include calcium supplements, active forms of vitamin D (such as calcitriol), and sometimes magnesium supplements.
Vitamin D Deficiency
In addition to Cholecalciferol, increasing dietary intake of vitamin D-rich foods (e.g., fatty fish, fortified dairy products) and getting more sunlight exposure can help. In some cases, prescription-strength vitamin D may be needed.
Chronic Kidney Disease
Patients may require active forms of vitamin D (e.g., calcitriol) rather than Cholecalciferol, as the kidneys may not convert vitamin D into its active form.
Malabsorption Syndromes
In cases where the body cannot absorb vitamin D properly, higher doses or injectable forms may be necessary. Treating the underlying condition (e.g., celiac disease, Crohn’s disease) is also important.
Hyperparathyroidism
Treatment may involve surgery to remove the overactive parathyroid gland, calcium and vitamin D supplementation, or medications like calcimimetics to reduce parathyroid hormone levels.
Psoriasis
Topical treatments such as vitamin D analogs (e.g., calcipotriene) or corticosteroids may be used. Light therapy and systemic treatments like biologics may also be considered.
Osteitis Deformans (Paget’s Disease of Bone)
Bisphosphonates (e.g., Alendronate) are commonly used to manage this condition. Adequate calcium and vitamin D intake is also important to support bone health.
Recent Updates on Cholecalciferol Research
Recent studies continue to explore the role of Cholecalciferol in various health conditions. Research suggests that maintaining adequate vitamin D levels may support immune function, reduce the risk of certain infections, and improve outcomes in chronic diseases such as cardiovascular disease and diabetes. Ongoing studies are also investigating the potential benefits of vitamin D in preventing or managing autoimmune conditions, including multiple sclerosis and rheumatoid arthritis. However, more research is needed to confirm these findings. Patients should always consult their healthcare provider before making any changes to their vitamin D intake.
For personalized advice on how Cholecalciferol may benefit your health, consider scheduling a telemedicine appointment with one of our providers today.
