Cariprazine: Uses, Dosage, Side Effects & Treatment Options

Summary of Key Points

Cariprazine is a prescription medication used to manage mental health conditions such as schizophrenia, bipolar disorder, and major depressive disorder. It works by balancing certain chemicals in the brain, which helps improve mood, thinking, and behavior. Typically, Cariprazine is taken once daily, and it’s important to follow your healthcare provider’s instructions closely. If you have any questions about your dosage or treatment plan, feel free to consult one of our telemedicine providers for guidance.

Names of Medication

US Brand Name: Vraylar (Cariprazine)

The generic name refers to the active ingredient in the medication, while the brand name is assigned by the manufacturer. The generic name is listed in parentheses.

Pharmacologic Category

Atypical Antipsychotics (also known as Second-Generation Antipsychotics)

Cariprazine Dosage

Cariprazine is prescribed to treat various mental health conditions in adults. The dosage will vary depending on the specific condition being treated. Always consult your doctor before making any changes to your dose or starting a new medication. You can also schedule a telemedicine appointment with one of our providers for personalized advice.

Cariprazine for Schizophrenia

Initial dose: 1.5 mg once daily

Maintenance dose: 1.5 mg to 6 mg once daily

Length of treatment: Long-term, as directed by your healthcare provider

Cariprazine for Bipolar Disorder (Manic or Mixed Episodes)

Initial dose: 1.5 mg once daily

Maintenance dose: 3 mg to 6 mg once daily

Length of treatment: Long-term, as directed by your healthcare provider

Cariprazine for Major Depressive Disorder (Adjunctive Treatment)

Initial dose: 1.5 mg once daily

Maintenance dose: 1.5 mg to 3 mg once daily

Length of treatment: Long-term, as directed by your healthcare provider

Cariprazine for Psychotic Disorders

Initial dose: 1.5 mg once daily

Maintenance dose: 1.5 mg to 6 mg once daily

Length of treatment: Long-term, as directed by your healthcare provider

Cariprazine for Depression (Adjunctive Treatment)

Initial dose: 1.5 mg once daily

Maintenance dose: 1.5 mg to 3 mg once daily

Length of treatment: Long-term, as directed by your healthcare provider

Cariprazine for Anxiety Disorders

Initial dose: 1.5 mg once daily

Maintenance dose: 1.5 mg to 6 mg once daily

Length of treatment: Long-term, as directed by your healthcare provider

Cariprazine for Schizoaffective Disorder

Initial dose: 1.5 mg once daily

Maintenance dose: 1.5 mg to 6 mg once daily

Length of treatment: Long-term, as directed by your healthcare provider

Cariprazine for Substance Use Disorders

Initial dose: 1.5 mg once daily

Maintenance dose: 1.5 mg to 6 mg once daily

Length of treatment: Long-term, as directed by your healthcare provider

Cariprazine for Post-Traumatic Stress Disorder (PTSD)

Initial dose: 1.5 mg once daily

Maintenance dose: 1.5 mg to 6 mg once daily

Length of treatment: Long-term, as directed by your healthcare provider

Cariprazine for Obsessive-Compulsive Disorder (OCD)

Initial dose: 1.5 mg once daily

Maintenance dose: 1.5 mg to 6 mg once daily

Length of treatment: Long-term, as directed by your healthcare provider

Dosage Forms and Strengths

Cariprazine is available in capsule form with the following strengths:

1. 1.5 mg
2. 3 mg
3. 4.5 mg
4. 6 mg

Administration Instructions for Cariprazine

Cariprazine is taken orally, usually once daily, with or without food. It’s important to take it at the same time each day to maintain consistent levels in your body. Swallow the capsule whole; do not crush, chew, or break it. If you miss a dose, take it as soon as you remember, unless it’s close to your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Do not double up on doses. Always follow your healthcare provider’s instructions, and if you have any questions, reach out to one of our telemedicine providers for assistance.

Contraindications for Cariprazine

A contraindication is a specific condition where a medication should not be used because it may cause harm. For Cariprazine, certain conditions could make taking the medication unsafe or lead to serious side effects. Below are the main contraindications for Cariprazine:

1. Hypersensitivity to Cariprazine or any of its components: If you have a known allergy to Cariprazine or its ingredients, taking it could lead to severe allergic reactions, such as rash, swelling, or difficulty breathing.
2. Severe liver impairment: Cariprazine is processed by the liver, and patients with severe liver disease may not metabolize the drug properly, leading to increased side effects or toxic levels of the medication.
3. Severe kidney impairment: Cariprazine is also excreted through the kidneys. If your kidneys are not functioning well, the drug may accumulate in your system, increasing the risk of side effects.

If you have any of these conditions, discuss alternative treatment options with your healthcare provider. You can schedule a telemedicine appointment with one of our providers to explore other options.

Drug-to-Drug Interactions with Cariprazine

Cariprazine can interact with other medications, potentially affecting its effectiveness or increasing the risk of side effects. Below are some common medications that may interact with Cariprazine:

1. Ketoconazole (Nizoral): This antifungal medication can increase Cariprazine levels in your body, raising the risk of side effects.
2. Rifampin (Rifadin): This antibiotic can reduce Cariprazine’s effectiveness by speeding up its breakdown in the liver.
3. Fluoxetine (Prozac): This antidepressant can increase Cariprazine levels, potentially leading to side effects like drowsiness or dizziness.
4. Carbamazepine (Tegretol): This seizure medication can reduce Cariprazine’s effectiveness by increasing its metabolism.

Always inform your healthcare provider about all medications you are taking, including over-the-counter drugs and supplements, to avoid harmful interactions. You can discuss your medication list with one of our telemedicine providers to ensure safe treatment.

Cariprazine in Pregnancy

Is it Safe to Take Cariprazine During Pregnancy?

Cariprazine is generally not recommended during pregnancy unless the potential benefits clearly outweigh the risks. While there is limited data on its use in pregnant women, animal studies have shown potential harm to the developing fetus. If you are pregnant or planning to become pregnant, it’s essential to have a thorough discussion with your healthcare provider about the risks and benefits of continuing Cariprazine. You can also schedule a telemedicine consultation with one of our providers to explore your options.

Cariprazine While Breastfeeding

Is it Safe to Take Cariprazine While Breastfeeding?

It is not yet known whether Cariprazine passes into breast milk. Due to the potential for serious side effects in a nursing infant, breastfeeding while taking Cariprazine is generally not recommended. If you are breastfeeding or planning to breastfeed, consult your healthcare provider to discuss alternative treatments. Our telemedicine providers are available to help you make an informed decision.

Estimated Cost of Cariprazine Medication

The cost of a 30-day supply of Cariprazine (typically 1.5 mg to 6 mg daily) without insurance can vary. With a GoodRx coupon, the price for a 30-day supply of Cariprazine (brand name: Vraylar) typically ranges from approximately $1,200 to $1,400. Prices may differ depending on the pharmacy and location. Be sure to check GoodRx or other discount programs for the most up-to-date pricing.

Possible Alternatives to Cariprazine

If Cariprazine is not suitable for you, or if you are considering other treatment options, several alternatives are available depending on your condition. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers to discuss these alternatives.

Schizophrenia Treatment Options

Alternative antipsychotic medications, such as Risperidone (Risperdal) or Aripiprazole (Abilify), may be considered. Cognitive behavioral therapy (CBT) and lifestyle changes, such as reducing stress and maintaining a healthy routine, can also help manage symptoms.

Bipolar Disorder Treatment Options

Mood stabilizers like Lithium or anticonvulsants such as Lamotrigine (Lamictal) are commonly used. Psychotherapy and establishing a regular sleep schedule can also be beneficial.

Major Depressive Disorder (MDD) Alternatives

Selective serotonin reuptake inhibitors (SSRIs) like Sertraline (Zoloft) or cognitive behavioral therapy (CBT) may be effective alternatives. Regular exercise and mindfulness practices can also improve mood.

Psychotic Disorders Treatment Options

Other antipsychotic medications, such as Quetiapine (Seroquel) or Olanzapine (Zyprexa), may be used. Psychotherapy and family support are also essential components of treatment.

Depression Treatment Alternatives

SSRIs like Escitalopram (Lexapro) or serotonin-norepinephrine reuptake inhibitors (SNRIs) like Venlafaxine (Effexor) are common alternatives. Lifestyle changes, such as regular physical activity and a balanced diet, can also help.

Anxiety Disorders Treatment Options

SSRIs like Paroxetine (Paxil) or Benzodiazepines such as Lorazepam (Ativan) may be considered. Relaxation techniques and cognitive behavioral therapy (CBT) are also effective.

Schizoaffective Disorder Treatment Options

A combination of antipsychotics like Paliperidone (Invega) and mood stabilizers like Valproate (Depakote) may be used. Psychotherapy and social support are key components of treatment.

Substance Use Disorders Treatment Options

Medications like Naltrexone (Vivitrol) or Buprenorphine (Suboxone) may help manage cravings. Behavioral therapies and support groups, such as 12-step programs, are also important.

Post-Traumatic Stress Disorder (PTSD) Treatment Options

SSRIs like Sertraline (Zoloft) or Prazosin for nightmares may be prescribed. Trauma-focused therapy, such as eye movement desensitization and reprocessing (EMDR), is also effective.

Obsessive-Compulsive Disorder (OCD) Treatment Options

SSRIs like Fluoxetine (Prozac) or cognitive behavioral therapy (CBT), specifically exposure and response prevention (ERP), are common treatments.

Recent Updates on Cariprazine Research

Recent studies have explored the potential benefits of Cariprazine in treating a broader range of psychiatric disorders. For example, ongoing research is investigating its effectiveness in managing negative symptoms of schizophrenia, such as social withdrawal and lack of motivation, which are often difficult to treat with other antipsychotics. Additionally, Cariprazine is being studied for its potential use in treating cognitive impairment associated with schizophrenia and bipolar disorder.

Another area of interest is Cariprazine as an adjunctive treatment for major depressive disorder (MDD). Early studies suggest that adding Cariprazine to standard antidepressant therapy may improve depressive symptoms in patients who have not responded well to other treatments.

As research continues, Cariprazine may become a more versatile option for treating a range of mental health conditions. If you are interested in learning more about new developments in Cariprazine treatment or want to discuss whether this medication is right for you, schedule a telemedicine appointment with one of our providers today.

James Kingsley

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