Rituximab Medication Profile

Summary or Key Points

Rituximab, a medication used in the treatment of several diseases, primarily works by targeting certain cells in your immune system. Indications include Non-Hodgkin’s Lymphoma, Chronic Lymphocytic Leukemia, Rheumatoid Arthritis, Granulomatosis with Polyangiitis, and Microscopic Polyangiitis. It’s essential to understand how to use this medication, its potential side effects, and the importance of following your healthcare provider’s instructions. If you have any concerns or questions about your treatment, our telemedicine providers are always here to help.

Names of Medication

US Brand Name: Rituxan (Rituximab)

The term ‘generic name’ refers to the official medical name of the active ingredient in the medication, in this case, Rituximab. We place the generic name in parentheses next to the brand name to make it clear what the active ingredient is.

Pharmacologic Category

Rituximab belongs to a group of medications known as monoclonal antibodies, specifically CD20-directed cytolytic antibodies. Other medications in this category include Obinutuzumab and Ofatumumab.

Dosing

Rituximab is used to treat several conditions in adults. The dosing varies based on the specific disease. Always consult your healthcare provider or one of our telemedicine professionals before adjusting your dose.

• Non-Hodgkin’s Lymphoma: 375 mg/m2 IV once weekly for 4 to 8 weeks.
• Chronic Lymphocytic Leukemia: 375 mg/m2 IV in the first cycle, then 500 mg/m2 IV in cycles 2-6, repeated every 28 days.
• Rheumatoid Arthritis: Two 1000 mg IV doses separated by two weeks. This treatment can be repeated after 24 weeks if needed.
• Granulomatosis with Polyangiitis and Microscopic Polyangiitis: 375 mg/m2 IV once weekly for four weeks.

Dosage Forms and Strengths

Rituximab is available in a solution for intravenous injection at a strength of 100 mg/10 mL and 500 mg/50 mL.

Administration Instructions

Rituximab should be administered under the supervision of a healthcare professional experienced in the use of cancer drugs. The medication is given as an infusion into a vein (intravenous, or IV). If you have any questions about administration, reach out to one of our telemedicine providers.

Adverse Reactions and Side Effects

Rituximab can cause side effects, though not everyone gets them. Consult with your healthcare provider or one of our telemedicine professionals if you experience any of the following:

• Common (may affect up to 1 in 10 people): infusion reactions (such as fever, chills), infections, body aches.
• Uncommon (may affect up to 1 in 100 people): serious infections, skin reactions, changes in blood pressure or heart rate.
• Rare (may affect up to 1 in 1,000 people): severe skin reactions, serious infusion reactions, damage to brain nerves (neurological disorders).

Contraindications

A contraindication refers to a specific situation in which a drug, procedure, or surgery should not be used because it may be harmful to the person. For Rituximab, contraindications include:

• Allergy to Rituximab or its components: This medication should not be used if you have known allergies to Rituximab or any of its ingredients because of the risk of severe allergic reactions.
• Severe active infections: Patients with severe active infections should not take Rituximab because the medication can further weaken the immune system, making it harder to fight off infections.

Drug to Drug Interactions

Some medications can interact with Rituximab, potentially altering its effects. Examples include:

• Live vaccines (such as MMR, Zostavax)
• Immunosuppressants (e.g., Cyclosporine, Tacrolimus)

Rituximab in Pregnancy

Rituximab should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Always consult with your healthcare provider or our telemedicine professionals to discuss any potential risks and benefits.

Rituximab while Breastfeeding

It’s currently unknown if Rituximab passes into breast milk. To ensure safety, nursing mothers may need to stop breastfeeding while receiving this medication. Consult with your healthcare provider or our telemedicine professionals for advice tailored to your situation.

Estimated Cost of Medication

As of the date this article was written, the estimated cost for a 30-day supply of Rituximab using a GoodRX coupon is approximately $5,000-$6,000. Prices may vary based on location and pharmacy.

Possible Alternatives

While Rituximab can be an effective treatment for several conditions, other treatments or lifestyle changes may also help manage these diseases. Always discuss these alternatives with your healthcare provider or one of our telemedicine professionals before making any changes to your treatment plan:

• Non-Hodgkin’s Lymphoma and Chronic Lymphocytic Leukemia: Alternative treatments can include other medications, radiation therapy, or stem cell transplant.
• Rheumatoid Arthritis: Lifestyle changes such as exercise, dietary changes, and physical therapy may help manage symptoms. Other medications may also be an option.
• Granulomatosis with Polyangiitis and Microscopic Polyangiitis: Corticosteroids or other immunosuppressive drugs may also be used to treat these conditions.

Recent Updates on Rituximab Research

Research into Rituximab continues to reveal its potential in treating various conditions. Recent studies suggest its potential use in treating autoimmune diseases such as Lupus. Another promising area of research is in neurology, where Rituximab is being studied for its effects on multiple sclerosis. Always consult with your healthcare provider or one of our telemedicine professionals to discuss the latest research related to your treatment.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.