Metoclopramide: A Comprehensive Medication Profile

Names of Medication

The medication commonly known as Metoclopramide is also sold in the United States under the brand name Reglan (Metoclopramide).

Pharmacologic Category

Metoclopramide falls under the pharmacologic category of prokinetic agents. Other medications in this category include drugs like Domperidone.

Dosing

The dosage of Metoclopramide varies depending on the condition it’s being used to treat. Always consult with your healthcare provider before making any changes to your medication regimen. The following is a general guide:

Gastroparesis

For the treatment of gastroparesis, the usual dosage is 10 mg, taken 4 times daily, 30 minutes before meals and at bedtime.

Gastroesophageal Reflux Disease (GERD)

For GERD, the usual dosage is 10 to 15 mg up to 4 times daily, 30 minutes before meals and at bedtime.

Nausea and Vomiting

For controlling nausea and vomiting, the dosage can range from 5 to 10 mg, taken 3 to 4 times daily.

Dosage Forms and Strengths

Metoclopramide is available in several forms and strengths, including:
Tablets: 5 mg and 10 mg.
Oral solution: 5 mg/5 mL.
Injection: 5 mg/mL.

Administration Instructions

Metoclopramide should be taken 30 minutes before meals and at bedtime. If using the liquid form, measure the dose carefully using a special measuring device/spoon.

Adverse Reactions and Side Effects

Like all medications, Metoclopramide can cause side effects. Always discuss potential side effects with your healthcare provider.

Drowsiness (Common)

Metoclopramide may cause drowsiness due to its action on the central nervous system. If this occurs, avoid driving or operating heavy machinery.

Restlessness (Common)

Restlessness or feeling jittery may occur. This is due to the drug’s effect on certain brain chemicals. If this side effect persists or worsens, notify your doctor or pharmacist promptly.

Tardive Dyskinesia (Rare)

In rare cases, Metoclopramide may cause tardive dyskinesia, a condition involving involuntary movements, often of the face and tongue. This side effect is more likely with long-term use and in older adults.

Contraindications to Taking Metoclopramide

A contraindication is a situation in which a drug should not be used because it may be harmful to the patient. Metoclopramide is contraindicated in certain situations:

Parkinson’s Disease

Metoclopramide can worsen symptoms of Parkinson’s disease due to its dopamine-blocking effects.

Gastrointestinal Obstruction

If there’s a blockage in your gastrointestinal tract, Metoclopramide should not be used as it could worsen the situation by increasing gut movement.

Pheochromocytoma Patients with a pheochromocytoma, a rare adrenal gland tumor, should not take Metoclopramide. The medication can cause a severe increase in blood pressure in these individuals.

Drug to Drug Interactions

Several drugs may interact significantly with Metoclopramide, such as:
Antipsychotics (Thorazine, Chlorpromazine) – Concurrent use may enhance the extrapyramidal effects.
Monoamine oxidase inhibitors (Nardil, Phenelzine) – These drugs may interact with Metoclopramide to cause an abrupt drop in blood pressure.
Always discuss potential drug interactions with your healthcare provider.

Metoclopramide in Pregnancy

Metoclopramide is categorized as Pregnancy Category B. This means that it’s not expected to harm an unborn baby. However, always consult your healthcare provider if you are pregnant or planning to become pregnant while using this medication.

Metoclopramide while Breastfeeding

Metoclopramide passes into breast milk but is unlikely to harm a nursing infant. Discuss the risks and benefits with your healthcare provider.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Metoclopramide, without insurance but using a GoodRX coupon, is around $10-$15 for the generic form. Remember, these prices are estimates and may vary depending on the pharmacy, location, and any negotiated agreements between pharmacies and pharmaceutical companies.
This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.

Legal Disclaimer

This article is intended for informational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare professional for diagnosis and treatment. Reliance on any information provided in this article is solely at your own risk.

Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.