Medication Profile: Domperidone

Summary or Key Points

Domperidone, sold under the brand name Motilium in the US, is primarily used to treat certain stomach disorders. Known for its effectiveness in managing symptoms of gastroparesis and off-label use for nausea and vomiting, Domperidone works by improving movement in the digestive system. However, it is important to understand its administration instructions and potential side effects. Always consult your healthcare provider, who can be accessed easily through our telemedicine services, before making any changes to your medication regimen.

Names of Medication

US Brand Name: Motilium (Domperidone)

A “generic name” is the official medical name for the active ingredient in the medicine, which is decided by an expert committee and is understood internationally (hence, it is the same name no matter where in the world you are). It’s the name we provide in parenthesis.

Pharmacologic Category

Domperidone falls under the pharmacologic category of “Prokinetic agents,” which also includes drugs such as Metoclopramide and Erythromycin.

Dosing

Domperidone is indicated for the following conditions in adults:

• Gastroparesis: The usual dose is 10 mg, three to four times a day. Treatment should not exceed a duration of 7 days.
• Nausea and Vomiting (Off-label use): The recommended dose is 10-20 mg, three to four times a day. The treatment duration varies based on the individual’s condition and response to therapy.

It is important to note that these dosages are general recommendations. Individual dosages can vary depending on specific circumstances. Always consult with one of our healthcare providers via our telemedicine services before adjusting your dose.

Dosage Forms and Strengths

Domperidone is available in the following forms and strengths:

• Tablets: 10 mg

Administration Instructions

Domperidone should be taken before meals. If taken after meals, absorption of the drug is somewhat delayed. Tablets should not be crushed or chewed, but swallowed whole with a full glass of water.

Adverse Reactions and Side Effects

While Domperidone can provide substantial relief from stomach disorders, it may cause some side effects. Potential side effects and their relative frequency include:

• Common (may affect up to 1 in 10 people): dry mouth
• Uncommon (may affect up to 1 in 100 people): loss of libido, rash, itchy skin
• Rare (may affect up to 1 in 1,000 people): irregular heartbeat, sudden cardiac death

If you experience any side effects, promptly contact one of our healthcare providers via our telemedicine services. Never hesitate to reach out to your healthcare provider for any concerns or clarifications.

Contraindications

A “contraindication” is a specific situation in which a drug, procedure, or surgery should not be used, as it may be harmful to the person. Domperidone has several contraindications, including:

• Known hypersensitivity to domperidone: This means if you’ve had an allergic reaction to this medication in the past, you should not take it.
• Patients with known prolongation of cardiac conduction intervals: This is related to heart rhythm and electrical activity. Domperidone can further affect this, possibly leading to dangerous rhythms.
• Patients with significant electrolyte disturbances: These imbalances can affect how your heart works, and Domperidone may worsen this condition.

Drug to Drug Interactions

Domperidone can interact with several other medications, potentially altering their effects. Some of these include:

• Ketoconazole (Nizoral)
• Erythromycin (Erythrocin)
• Ritonavir (Norvir)

Always provide your healthcare provider with a complete list of medications you’re taking, including over-the-counter drugs, vitamins, and supplements, to avoid any potential drug interactions. You can discuss this with our healthcare providers available through telemedicine.

Domperidone in Pregnancy

Domperidone should only be used during pregnancy if the potential benefits to the mother outweigh the potential risks to the fetus. Discuss the use of this medication with one of our healthcare providers through our telemedicine services if you are pregnant or planning to become pregnant.

Domperidone while Breastfeeding

Domperidone passes into breast milk but is considered safe for use while breastfeeding under a healthcare provider’s guidance. However, the nursing infant should be monitored for possible side effects, such as irritability or disturbed sleep. Speak to one of our telemedicine providers to understand more.

Estimated Cost of Medication

The estimated cost of a 30-day supply of Domperidone (10 mg tablets) without insurance, using a GoodRx coupon, is approximately $30.

Possible Alternatives

For Gastroparesis, dietary modifications, such as eating smaller, more frequent meals, can be helpful. Metoclopramide is another medication option.

In cases of Nausea and Vomiting, non-pharmacological approaches such as ginger or acupuncture may be beneficial. Medications like Ondansetron or Promethazine can also be considered.

Remember, it’s crucial to discuss any potential alternatives with one of our healthcare providers via our telemedicine services before making changes to your treatment plan.

Recent Updates on Domperidone Research

Recent research on Domperidone indicates its potential in treating other conditions like cyclic vomiting syndrome and functional dyspepsia, though more studies are needed. Additionally, a new formulation of Domperidone is being investigated to allow for sublingual administration, potentially increasing its efficacy. Always consult our telemedicine healthcare providers for the latest information relevant to your condition and treatment.

Brief Legal Disclaimer

This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.
Brief Legal Disclaimer: This article is for informational purposes only and not intended as medical advice. Always consult a healthcare professional for diagnosis and treatment. Reliance on the information provided here is at your own risk.