Vandetanib Medication: Uses, Dosage, Side Effects & Interactions

Summary of Key Points

Vandetanib is a prescription medication used to treat specific types of thyroid and lung cancers. It works by blocking certain proteins that encourage cancer cells to grow and spread. Vandetanib is typically prescribed for advanced or metastatic cancers, especially when other treatments have not been effective. Always consult your healthcare provider before starting or adjusting this medication. You can schedule a telemedicine appointment with us to discuss your treatment options.

Names of Medication

US Brand Name: Caprelsa

Generic Name: Vandetanib

The generic name refers to the active ingredient, while the brand name is assigned by the manufacturer. In this article, the generic name is listed in parentheses.

Pharmacologic Category

Tyrosine Kinase Inhibitor (TKI)

VEGFR (Vascular Endothelial Growth Factor Receptor) Inhibitor

EGFR (Epidermal Growth Factor Receptor) Inhibitor

Vandetanib Dosage

Vandetanib is used to treat various cancers. The dosage and frequency depend on the specific condition being treated. Always follow your doctor’s instructions and consult them before making any changes to your dose. If you need assistance managing your medication, schedule a telemedicine consultation with one of our providers.

Medullary Thyroid Carcinoma

Adult Dose: 300 mg orally once daily. Treatment continues as long as the patient benefits and tolerates the medication well.

Non-Small Cell Lung Cancer

Adult Dose: 300 mg orally once daily. The duration of treatment depends on the patient’s response and any side effects experienced.

Thyroid Cancer (Advanced, Metastatic, Anaplastic, Follicular, Papillary)

Adult Dose: 300 mg orally once daily. Treatment is typically long-term, with adjustments based on your doctor’s ongoing monitoring.

Dosage Forms and Strengths

Tablet, oral: 100 mg

Tablet, oral: 300 mg

Administration Instructions for Vandetanib

Take Vandetanib by mouth, with or without food, at the same time each day. Swallow the tablet whole with water; do not crush or chew it. If you miss a dose, take it as soon as you remember, unless it’s close to your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once. Always follow your doctor’s instructions carefully.

Vandetanib Side Effects and Adverse Reactions

Like all medications, Vandetanib can cause side effects. Some are common, while others are rare but more serious. If you experience any side effects, contact your healthcare provider immediately. You can also schedule a telemedicine visit with us to discuss any concerns.

Common Side Effects:

1. Diarrhea: Frequent, loose stools are common. Stay hydrated and inform your doctor if it persists.
2. Rash: Skin irritation or rash may occur. Use gentle skincare products and avoid excessive sun exposure.
3. High Blood Pressure: Vandetanib can raise blood pressure, so regular monitoring is important.

Serious Side Effects (Less Common):

1. Heart Rhythm Problems (QT Prolongation): Vandetanib can affect your heart’s electrical activity, potentially causing serious irregular heartbeats. Your doctor will monitor your heart function regularly.
2. Liver Problems: Signs include yellowing of the skin or eyes, dark urine, or severe fatigue. Contact your doctor immediately if you notice these symptoms.
3. Severe Diarrhea: If diarrhea becomes uncontrollable or leads to dehydration, seek medical attention immediately.

Contraindications for Vandetanib

A contraindication is a medical reason or condition that makes it unsafe to take a particular medication. If you have any of the following conditions or risk factors, you should not take Vandetanib, as it may cause harm or worsen your condition.

1. Long QT syndrome: Vandetanib can prolong the QT interval, which is the time it takes for the heart to recharge between beats. If you have long QT syndrome, Vandetanib can increase your risk of life-threatening heart rhythm problems.
2. Severe liver disease: Vandetanib is processed by the liver. If your liver isn’t functioning properly, the medication may accumulate, leading to increased side effects or toxicity.
3. Hypocalcemia (low calcium levels): Vandetanib can further lower calcium levels, potentially causing muscle spasms, heart problems, or seizures.
4. Hypokalemia (low potassium levels): Low potassium levels can increase the risk of heart rhythm problems, especially when combined with Vandetanib’s effects on the heart.
5. Hypomagnesemia (low magnesium levels): Similar to potassium, low magnesium levels can heighten the risk of dangerous heart rhythms when taking Vandetanib.

If you have any of these conditions, discuss them with your healthcare provider before starting Vandetanib. You can schedule a telemedicine appointment with one of our providers to review your medical history and determine if Vandetanib is right for you.

Vandetanib Drug Interactions

Vandetanib can interact with other medications, potentially increasing the risk of side effects or reducing treatment effectiveness. Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements. Some medications that interact with Vandetanib include:

1. Amiodarone (Pacerone): Used to treat irregular heartbeats, but when combined with Vandetanib, it can increase the risk of dangerous heart rhythm problems.
2. Clarithromycin (Biaxin): An antibiotic that can increase Vandetanib levels in your body, potentially leading to more severe side effects.
3. Ketoconazole (Nizoral): An antifungal medication that can also increase Vandetanib concentration in your blood, raising the risk of side effects.
4. Ondansetron (Zofran): Used to prevent nausea and vomiting, but it can increase the risk of heart rhythm problems when taken with Vandetanib.
5. Warfarin (Coumadin): A blood thinner that may interact with Vandetanib, increasing the risk of bleeding or clotting issues.

Always consult your healthcare provider before starting or stopping any medications while on Vandetanib. If you have concerns about drug interactions, you can speak with one of our providers through a telemedicine visit.

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Vandetanib in Pregnancy

Is it safe to take Vandetanib when pregnant?

No, Vandetanib is not considered safe during pregnancy. It can harm an unborn baby, potentially leading to birth defects or pregnancy loss. If you are pregnant or planning to become pregnant, it is crucial to discuss alternative treatments with your healthcare provider. Women of childbearing age should use effective contraception during treatment and for at least four months after the last dose of Vandetanib.

Vandetanib while Breastfeeding

Is it safe to take Vandetanib while breastfeeding?

No, Vandetanib is not recommended while breastfeeding. Although it is unclear whether Vandetanib passes into breast milk, the risk of serious side effects in a nursing infant means breastfeeding should be avoided during treatment and for at least four months after the last dose. If you are breastfeeding or plan to breastfeed, consult your healthcare provider to discuss your options.

Estimated Cost of Vandetanib Medication

The estimated cost of a 30-day supply of Vandetanib without insurance, using a GoodRX coupon, ranges from $13,000 to $15,000. Prices may vary depending on the pharmacy and location. Be sure to check with your pharmacy or use a coupon service like GoodRX to find the most affordable price available.

Possible Alternatives to Vandetanib

If Vandetanib is not suitable for you, there may be alternative medications or lifestyle changes that can help manage your condition. It is essential to discuss these options with your healthcare provider before making any changes to your treatment plan. Below are some alternatives based on specific conditions:

1. Medullary thyroid carcinoma: Other targeted therapies, such as cabozantinib (Cometriq) or lenvatinib (Lenvima), may be considered. Surgery and radiation therapy are also potential options.
2. Non-small cell lung cancer: Depending on the stage of the cancer, alternatives may include chemotherapy, immunotherapy (such as pembrolizumab), or other targeted therapies like osimertinib (Tagrisso).
3. Thyroid cancer: Radioactive iodine therapy, surgery, or other targeted therapies like sorafenib (Nexavar) may be used as alternatives.
4. Lung cancer: In addition to chemotherapy and radiation, immunotherapy or targeted therapies like erlotinib (Tarceva) may be options.
5. Advanced thyroid cancer: Targeted therapies like lenvatinib (Lenvima) or sorafenib (Nexavar) may be considered, along with radiation therapy.
6. Metastatic thyroid cancer: Radioactive iodine therapy, targeted therapies, or participation in clinical trials may be options for patients with metastatic disease.
7. Anaplastic thyroid carcinoma: This aggressive form of thyroid cancer may require a combination of surgery, radiation, and chemotherapy. Targeted therapies or clinical trials may also be considered.
8. Follicular thyroid carcinoma: Radioactive iodine therapy, surgery, or targeted therapies like lenvatinib (Lenvima) may be alternative treatments.
9. Papillary thyroid carcinoma: Surgery, radioactive iodine therapy, or targeted therapies may be considered, depending on the stage and spread of the disease.

Always consult your healthcare provider before making any changes to your treatment plan. If you are interested in exploring alternative treatments, you can schedule a telemedicine appointment with one of our providers to discuss your options.

Recent Updates on Vandetanib Research

Recent studies have focused on improving the safety and effectiveness of Vandetanib, particularly when used in combination with other therapies. Researchers are exploring how Vandetanib can be paired with immunotherapy and other targeted treatments to enhance outcomes for patients with advanced thyroid cancer and other types of cancer. Ongoing clinical trials are also investigating the use of Vandetanib in combination with chemotherapy for non-small cell lung cancer.

As research continues, new findings may lead to improved treatment protocols and potentially expanded uses for Vandetanib. If you are interested in learning more about clinical trials or new treatment options, speak with your healthcare provider. You can also schedule a telemedicine visit with one of our providers to discuss the latest research and how it may apply to your treatment plan.

James Kingsley

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