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Sunitinib Treatment: Uses, Dosage, and Side Effects Explained
Summary of Key Points
Sunitinib is a prescription medication used to treat certain types of cancer, including renal cell carcinoma, gastrointestinal stromal tumors, and pancreatic neuroendocrine tumors. It works by blocking proteins that encourage cancer cell growth. Sunitinib is taken orally and is available in different strengths. Like all medications, it may cause side effects, so it’s important to follow your doctor’s instructions carefully. If you have any concerns, consider consulting one of our telemedicine providers today.
Names of Medication
US Brand Name: Sutent (Sunitinib)
The generic name refers to the active ingredient in the medication. In this case, Sunitinib is the generic name, listed in parentheses.
Pharmacologic Category
Tyrosine Kinase Inhibitors
Vascular Endothelial Growth Factor (VEGF) Inhibitors
Sunitinib Dosage and Treatment Schedules
Sunitinib is prescribed for various cancers, and the dosing schedule and treatment duration depend on the specific type of cancer being treated. Always consult your doctor before making any changes to your dose or stopping the medication. If you need to speak with a healthcare provider, you can schedule a telemedicine appointment with us.
Sunitinib for Renal Cell Carcinoma
Dosage: 50 mg once daily
Frequency: 4 weeks on treatment, followed by 2 weeks off
Length of Treatment: As directed by your doctor
Sunitinib for Gastrointestinal Stromal Tumors (GIST)
Dosage: 50 mg once daily
Frequency: 4 weeks on treatment, followed by 2 weeks off
Length of Treatment: As directed by your doctor
Sunitinib for Pancreatic Neuroendocrine Tumors
Dosage: 37.5 mg once daily
Frequency: Continuous daily dosing
Length of Treatment: As directed by your doctor
Sunitinib for Neuroendocrine Tumors
Dosage: 37.5 mg once daily
Frequency: Continuous daily dosing
Length of Treatment: As directed by your doctor
Sunitinib for Thyroid Cancer
Dosage: 50 mg once daily
Frequency: 4 weeks on treatment, followed by 2 weeks off
Length of Treatment: As directed by your doctor
Sunitinib for Hepatocellular Carcinoma
Dosage: 50 mg once daily
Frequency: 4 weeks on treatment, followed by 2 weeks off
Length of Treatment: As directed by your doctor
Sunitinib for Breast Cancer
Dosage: 37.5 mg once daily
Frequency: Continuous daily dosing
Length of Treatment: As directed by your doctor
Sunitinib for Colorectal Cancer
Dosage: 50 mg once daily
Frequency: 4 weeks on treatment, followed by 2 weeks off
Length of Treatment: As directed by your doctor
Sunitinib for Ovarian Cancer
Dosage: 37.5 mg once daily
Frequency: Continuous daily dosing
Length of Treatment: As directed by your doctor
Sunitinib for Lung Cancer
Dosage: 50 mg once daily
Frequency: 4 weeks on treatment, followed by 2 weeks off
Length of Treatment: As directed by your doctor
Dosage Forms and Strengths of Sunitinib
Capsule: 12.5 mg, 25 mg, 37.5 mg, 50 mg
Administration Instructions for Sunitinib
Sunitinib is taken orally, typically once a day, with or without food. Swallow the capsule whole with water. Do not crush or chew the capsule. It’s important to take the medication at the same time each day to maintain consistent levels in your body. If you miss a dose, take it as soon as you remember, unless it’s close to your next scheduled dose. In that case, skip the missed dose and continue with your regular schedule. Do not take two doses at once.
Contraindications for Sunitinib Treatment
A contraindication is a specific condition where a medication should not be used because it could cause harm. If you have any of the following conditions, Sunitinib may not be safe for you. Always inform your healthcare provider about your complete medical history before starting any new medication.
Allergy to Sunitinib or its ingredients: If you’ve had an allergic reaction to Sunitinib, taking it again could cause serious symptoms such as swelling, difficulty breathing, or a severe rash.
Severe liver disease: Sunitinib is processed by the liver. If your liver is not functioning properly, the drug may build up in your system, leading to increased side effects or toxicity.
Uncontrolled high blood pressure (hypertension): Sunitinib can raise blood pressure. If your blood pressure is already high and not well-controlled, this medication could increase your risk of complications such as stroke or heart attack.
Recent heart problems: If you’ve recently experienced a heart attack, heart failure, or other serious heart conditions, Sunitinib may increase the risk of further heart complications.
Bleeding disorders: Sunitinib can increase the risk of bleeding. If you have a condition that affects your blood’s ability to clot, this medication could lead to dangerous bleeding episodes.
Drug-to-Drug Interactions with Sunitinib
Certain medications can interact with Sunitinib, affecting how it works or increasing the risk of side effects. Be sure to inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements. Below are some medications that may interact with Sunitinib:
Ketoconazole (Nizoral): This antifungal medication can increase Sunitinib levels in your body, raising the risk of side effects.
Rifampin (Rifadin): This antibiotic can reduce Sunitinib’s effectiveness by speeding up its breakdown in the liver.
Warfarin (Coumadin): Taking Sunitinib with blood thinners like warfarin can increase the risk of bleeding.
Dexamethasone (Decadron): This corticosteroid may reduce Sunitinib’s effectiveness by affecting how it is processed in the body.
St. John’s Wort: This herbal supplement can reduce Sunitinib’s effectiveness by speeding up its breakdown in the liver.
Sunitinib in Pregnancy
Is it safe to take Sunitinib when pregnant?
Sunitinib is not considered safe during pregnancy. This cancer medication can harm an unborn baby, potentially leading to birth defects or miscarriage. If you are pregnant or planning to become pregnant, it is important to avoid taking Sunitinib. Women of childbearing age should use effective contraception while undergoing Sunitinib treatment and for at least four weeks after stopping the medication. If you become pregnant while taking Sunitinib, contact your healthcare provider immediately to discuss your options.
Sunitinib while Breastfeeding
Is it safe to take Sunitinib while breastfeeding?
Sunitinib is not recommended during breastfeeding. Although it is unclear whether Sunitinib passes into breast milk, the potential for serious side effects in a nursing infant suggests that breastfeeding should be avoided while on this medication. If you are prescribed Sunitinib, discuss alternative feeding options with your healthcare provider.
Estimated Cost of Sunitinib
The cost of Sunitinib can vary depending on your location and pharmacy. Without insurance, a 30-day supply of Sunitinib (50 mg) may range from $15,000 to $17,000. However, with a GoodRx coupon, the price may be reduced to approximately $12,000 to $14,000. Be sure to check with your pharmacy and explore financial assistance programs if needed.
Possible Alternatives to Sunitinib
If Sunitinib is not suitable for you, there are alternative medications and lifestyle changes that may help manage your condition. Always consult your healthcare provider before making any changes to your treatment plan. You can also schedule a telemedicine appointment with one of our providers for personalized advice.
Renal Cell Carcinoma Alternatives
For renal cell carcinoma, alternatives to Sunitinib include other targeted therapies such as Pazopanib (Votrient) or immunotherapy drugs like Nivolumab (Opdivo). Maintaining a healthy diet and engaging in regular exercise can also support your overall health.
Gastrointestinal Stromal Tumors Alternatives
For gastrointestinal stromal tumors, Imatinib (Gleevec) is often used as an alternative. In some cases, surgery may also be an option.
Pancreatic Neuroendocrine Tumors Alternatives
For pancreatic neuroendocrine tumors, Everolimus (Afinitor) and Lanreotide (Somatuline) are other treatment options. Dietary changes and managing blood sugar levels may also be beneficial.
Neuroendocrine Tumors Alternatives
For neuroendocrine tumors, Octreotide (Sandostatin) and Everolimus (Afinitor) are commonly used alternatives. Regular monitoring and a balanced diet can help manage symptoms.
Thyroid Cancer Alternatives
For thyroid cancer, Sorafenib (Nexavar) or Lenvatinib (Lenvima) are potential alternatives. Monitoring thyroid hormone levels and maintaining a healthy lifestyle can also help manage the condition.
Hepatocellular Carcinoma Alternatives
For hepatocellular carcinoma, Sorafenib (Nexavar) and Lenvatinib (Lenvima) are commonly used alternatives. Avoiding alcohol and maintaining a balanced diet can support liver health.
Breast Cancer Alternatives
For breast cancer, hormonal therapies like Tamoxifen or chemotherapy options such as Doxorubicin (Adriamycin) may be considered alternatives. Regular exercise and a healthy diet can also support your treatment.
Colorectal Cancer Alternatives
For colorectal cancer, chemotherapy drugs like Capecitabine (Xeloda) or targeted therapies such as Bevacizumab (Avastin) may be alternatives. A high-fiber diet and regular screenings are important lifestyle changes that can help manage the condition.
Ovarian Cancer Alternatives
For ovarian cancer, chemotherapy with drugs like Paclitaxel (Taxol) or targeted therapies such as Olaparib (Lynparza) may be alternatives. Regular physical activity and a nutritious diet can also be beneficial.
Lung Cancer Alternatives
For lung cancer, alternatives include chemotherapy with Cisplatin or targeted therapies like Pembrolizumab (Keytruda). Quitting smoking and maintaining a healthy lifestyle are essential for lung health.
Recent Updates on Sunitinib Research
Recent studies on Sunitinib have focused on its effectiveness when combined with other therapies. Ongoing research is exploring the use of Sunitinib alongside immunotherapy drugs to enhance treatment outcomes for renal cell carcinoma and other cancers. Additionally, researchers are investigating biomarkers that could help predict which patients will respond best to Sunitinib, potentially leading to more personalized treatment plans.
As of 2023, clinical trials are also evaluating the use of Sunitinib in cancers beyond its current approved indications, such as certain types of breast and lung cancers. These studies aim to expand the potential uses of Sunitinib and improve outcomes for a broader range of patients. If you are interested in participating in a clinical trial, talk to your healthcare provider or schedule a telemedicine consultation with one of our providers to learn more.
