Dasatinib: Uses, Dosage, and Side Effects Explained

Summary of Key Points

Dasatinib is a prescription medication commonly used to treat specific types of leukemia, including chronic myeloid leukemia (CML) and acute lymphoblastic leukemia (ALL). It works by blocking abnormal proteins that encourage cancer cells to grow and multiply. This oral medication is typically prescribed for long-term use. Always consult your healthcare provider before starting or adjusting your dosage. For personalized care, you may also consider scheduling a telemedicine appointment with us.

Names of the Medication

US Brand Name: Sprycel

Generic Name: Dasatinib

The generic name, Dasatinib, refers to the active ingredient’s chemical composition, while Sprycel is the brand name assigned by the manufacturer.

Pharmacologic Category

Category: Tyrosine Kinase Inhibitor

Other medications in this category include:

1. Imatinib
2. Nilotinib
3. Bosutinib

Dasatinib Dosage

Dasatinib is prescribed to treat various types of leukemia and other cancers. Dosages may differ depending on the specific condition being treated. Always follow your healthcare provider’s instructions and consult them before making any changes to your dosage. If you need additional guidance, you can schedule a telemedicine consultation with us.

Chronic Myeloid Leukemia (CML)

Initial Dose: 100 mg orally once daily

Duration: Long-term treatment, as directed by your doctor

Acute Lymphoblastic Leukemia (ALL)

Initial Dose: 140 mg orally once daily

Duration: Long-term treatment, as directed by your doctor

Philadelphia Chromosome-Positive Leukemia

Initial Dose: 140 mg orally once daily

Duration: Long-term treatment, as directed by your doctor

Myeloproliferative Disorders

Initial Dose: 100 mg orally once daily

Duration: Long-term treatment, as directed by your doctor

Non-Hodgkin Lymphoma

Initial Dose: 140 mg orally once daily

Duration: Long-term treatment, as directed by your doctor

Acute Myeloid Leukemia (AML)

Initial Dose: 140 mg orally once daily

Duration: Long-term treatment, as directed by your doctor

Chronic Lymphocytic Leukemia (CLL)

Initial Dose: 100 mg orally once daily

Duration: Long-term treatment, as directed by your doctor

Multiple Myeloma

Initial Dose: 140 mg orally once daily

Duration: Long-term treatment, as directed by your doctor

Solid Tumors

Initial Dose: 140 mg orally once daily

Duration: Long-term treatment, as directed by your doctor

Mastocytosis

Initial Dose: 100 mg orally once daily

Duration: Long-term treatment, as directed by your doctor

Dosage Forms and Strengths

Dasatinib is available in tablet form in the following strengths:

1. 20 mg
2. 50 mg
3. 70 mg
4. 80 mg
5. 100 mg
6. 140 mg

Administration Instructions

Dasatinib should be taken orally, with or without food. Swallow the tablet whole; do not crush or chew it. If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time. Always follow your healthcare provider’s instructions. If you have any questions or concerns about your treatment, feel free to reach out to us via telemedicine for assistance.

Adverse Reactions and Side Effects

Like all medications, Dasatinib may cause side effects. While not everyone will experience these, it’s important to be aware of them. If you experience severe side effects, contact your healthcare provider immediately. You can also schedule a telemedicine appointment with us for further support.

Common Side Effects (Affecting More Than 10% of Patients)

1. Fluid retention: Swelling in the hands, feet, or around the eyes
2. Diarrhea: Loose or watery stools
3. Fatigue: Feeling unusually tired or weak
4. Headache: Mild to moderate headaches

Less Common Side Effects (Affecting 1-10% of Patients)

1. Shortness of breath: Difficulty breathing or feeling out of breath
2. Skin rash: Red, itchy, or irritated skin
3. Infections: Increased risk of infections due to lower white blood cell counts

Rare but Serious Side Effects (Affecting Less Than 1% of Patients)

1. Lung problems: Severe shortness of breath or chest pain
2. Heart problems: Irregular heartbeat or chest pain
3. Bleeding: Unusual bruising or bleeding, including in the stomach or intestines

Contraindications

A contraindication refers to a specific condition or circumstance in which using a particular medication could be harmful. Before starting a new medication like Dasatinib, it is crucial to identify whether any contraindications apply to you. This step helps ensure your safety and the effectiveness of your treatment.

Contraindications for Dasatinib

Allergy to Dasatinib: Avoid taking Dasatinib if you are allergic to it or any of its components. Allergic reactions can range from mild symptoms, such as a rash, to severe reactions, including difficulty breathing or swelling. If you suspect an allergic reaction, seek medical attention immediately.

Uncontrolled or severe heart disease: Dasatinib can affect heart function. If you have conditions such as congestive heart failure or uncontrolled arrhythmias, taking this medication may exacerbate your condition and pose serious health risks.

Low platelet or white blood cell counts: Dasatinib can further lower blood cell counts, which may increase the risk of infections or bleeding. Individuals with pre-existing low levels of platelets or white blood cells should exercise caution and consult their healthcare provider before starting this medication.

Severe liver disease: Since the liver is responsible for processing Dasatinib, impaired liver function can lead to the medication accumulating in your body. This increases the likelihood of adverse effects and may require dosage adjustments or alternative treatments.

Drug-to-Drug Interactions

Dasatinib can interact with other medications, potentially altering its effectiveness or increasing the risk of side effects. To minimize these risks, always inform your healthcare provider about all the medications you are taking, including prescription drugs, over-the-counter medications, and dietary supplements.

Medications That Interact with Dasatinib

Proton pump inhibitors (PPIs): Medications such as omeprazole (Prilosec) and esomeprazole (Nexium) can reduce the absorption of Dasatinib, making it less effective. Your healthcare provider may recommend alternative options to manage acid reflux or heartburn.

Antacids: Over-the-counter antacids like calcium carbonate (Tums) or aluminum hydroxide (Maalox) can interfere with Dasatinib absorption. To avoid this interaction, take antacids at least two hours before or after your Dasatinib dose.

Strong CYP3A4 inhibitors: Drugs such as ketoconazole (Nizoral) and ritonavir (Norvir) can increase the levels of Dasatinib in your bloodstream, heightening the risk of side effects. Your doctor may adjust your dosage or suggest alternative medications.

Strong CYP3A4 inducers: Medications like rifampin (Rifadin) and phenytoin (Dilantin) can lower Dasatinib levels in your body, reducing its effectiveness. Your healthcare provider may need to modify your treatment plan if you are taking these drugs.

Blood thinners: Combining Dasatinib with blood-thinning medications such as warfarin (Coumadin) or aspirin can increase the risk of bleeding. If you are on blood thinners, your doctor will carefully monitor your treatment to minimize potential complications.

Dasatinib in Pregnancy

Is It Safe to Take Dasatinib During Pregnancy?

Dasatinib is not considered safe during pregnancy. It can harm a developing fetus, potentially leading to birth defects or miscarriage. If you are pregnant or planning to become pregnant, it is essential to discuss alternative treatment options with your healthcare provider. Women of childbearing age should use reliable contraception while taking Dasatinib and for a specified period after discontinuing the medication. If you become pregnant while on Dasatinib, contact your healthcare provider immediately to discuss the next steps.

Dasatinib While Breastfeeding

Is It Safe to Take Dasatinib While Breastfeeding?

Breastfeeding is not recommended while taking Dasatinib. Although it is unclear whether Dasatinib passes into breast milk, the potential for serious side effects in a nursing infant makes it unsafe. If you are currently breastfeeding or planning to breastfeed, consult your healthcare provider to explore alternative treatments or feeding options for your baby.

Estimated Cost of Dasatinib Medication

The cost of Dasatinib can vary based on your location and the pharmacy you use. Without insurance, a 30-day supply of Dasatinib (Sprycel) typically ranges from $11,000 to $12,000 when using a GoodRx coupon. Prices may fluctuate, so it is advisable to check with your pharmacy or use a discount service like GoodRx to find the most up-to-date pricing information.

Possible Alternatives to Dasatinib

There are several alternative treatments and lifestyle modifications available for conditions typically managed with Dasatinib. However, it is essential to consult your healthcare provider before making any changes to your treatment plan. If you’re considering exploring these options, scheduling a telemedicine consultation with one of our providers can be a convenient first step.

Alternatives for Chronic Myeloid Leukemia (CML)

1. Imatinib (Gleevec)
2. Nilotinib (Tasigna)
3. Bone marrow transplant (in specific cases)

Alternatives for Acute Lymphoblastic Leukemia (ALL)

1. Chemotherapy (e.g., vincristine, methotrexate)
2. Tyrosine kinase inhibitors (e.g., imatinib)
3. Stem cell transplant

Alternatives for Philadelphia Chromosome-Positive Leukemia

1. Imatinib (Gleevec)
2. Nilotinib (Tasigna)
3. Stem cell transplant

Alternatives for Myeloproliferative Disorders

1. Hydroxyurea
2. Interferon therapy
3. JAK inhibitors (e.g., ruxolitinib)

Alternatives for Non-Hodgkin Lymphoma

1. Chemotherapy (e.g., CHOP regimen)
2. Radiation therapy
3. Targeted therapies (e.g., rituximab)

Alternatives for Acute Myeloid Leukemia (AML)

1. Chemotherapy (e.g., cytarabine, daunorubicin)
2. Targeted therapies (e.g., midostaurin)
3. Stem cell transplant

Alternatives for Chronic Lymphocytic Leukemia (CLL)

1. Bruton’s tyrosine kinase inhibitors (e.g., ibrutinib)
2. Monoclonal antibodies (e.g., rituximab)
3. Stem cell transplant

Alternatives for Multiple Myeloma

1. Proteasome inhibitors (e.g., bortezomib)
2. Immunomodulatory drugs (e.g., lenalidomide)
3. Stem cell transplant

Alternatives for Solid Tumors

1. Chemotherapy
2. Targeted therapies (e.g., bevacizumab)
3. Radiation therapy

Alternatives for Mastocytosis

1. Antihistamines
2. Leukotriene inhibitors
3. Tyrosine kinase inhibitors (e.g., midostaurin)

Recent Updates on Dasatinib Research

Ongoing research continues to explore the potential of Dasatinib beyond its current approved uses. Studies are investigating its effectiveness in treating other cancers, such as solid tumors and certain types of lymphoma. Additionally, researchers are examining how combining Dasatinib with other targeted therapies might enhance outcomes for patients with treatment-resistant forms of leukemia.

Preliminary findings from clinical trials suggest that pairing Dasatinib with immunotherapy could strengthen the immune system’s ability to fight cancer cells. As research evolves, it’s important to stay informed about these developments. Always consult your healthcare provider to understand how emerging studies may influence your treatment options.

James Kingsley

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